Detecting Alzheimer’s markers up to 5 years before symptom onset – inside the Quebec teams research

The study led by the doctoral student Mohamed Raâfet Ben Khedher and postdoctoral student Mohamed Haddad, was directed by Professor Charles Ramassamy of the Institut national de la recherche scientifique (INRS), was recently published in the prestigious scientific journal Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI).

The results show that the group of researchers was able to detect the markers for Alzheimer’s 5 years before symptoms were present.

The diagnosis of Alzeheimer’s

The press release describes the diagnosis of Alzheimer’s as being “usually based on a series of psychometric tests assessing cognitive function, brain imaging and cerebrospinal fluid analysis.”

Professeur Ramassamy who directed the study said that these tests have their limitations. “The lumbar puncture is invasive, while brain imaging is expensive and not 100% reliable. This complicates regular follow-up,” 

The research team found two markers that are detectable through a blood test. This enables them to follow the progression of the disease.

Professeur Ramassamy hopes to be able to do more studies in the future. This would allow him to determine the progression of markers after the onset of symptoms. His research on the markers is located in the vesicles, which opens up the possibility for studying other diseases like vascular dementia.

About INRS

INRS is a university that is exclusively dedicated to graduate level research and training. It was created in 1969 and since has played an active role in Quebec’s economic, social, and cultural development and is ranked first for research intensity in Quebec and in Canada. INRS received $108,400 in 2018-2019 for research funding – this ranked 1st in all of Canada.

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